African Journal of Biotechnology

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Antioxidative, anticholinesterase and antityrosinase activities of the red alga Grateloupia lancifolia extracts

Han Nguyen, Sang Moo Kim


The solvent extracts of a red alga Grateloupia lancifolia were used to evaluate biofunctional activities. The diethyl ether extract showed the highest total phenolic content and biological activities. The IC50 value of the diethyl ether extract on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was 113.8 μg/ml. In the reducing power test, the half maximal effective concentration (EC50) values of the diethyl ether, water and methanol extracts were 1.21, 1.74 and 3.96 mg/ml, respectively. In the linoleic acid system, all the extracts had significantly higher inhibitory activity than α-tocopherol (p < 0.05). The diethyl ether extract had the highest tyrosinase, acetylcholinesterase and butyrylcholinesterase inhibitory activities with the IC50 values of 47.8, 99.8 and 23.7 μg/ml, respectively. Therefore, the G. lancifolia extract could be used as a potential source for the development of dietary foods, food products and additives.

Key words: Grateloupia lancifolia, red alga, anticholinesterase, antioxidant, antityrosinase.
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