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Pharmacokinetics of mequindox after intravenous and intramuscular administration to goat

Yinqian Li
Wenyan Xie
Xiaoying Zhang
Zehua Tian
Caiju Hao


Pharmacokinetics and bioavailability of mequindox were determined after single intravenous (i.v.) or intramuscular (i.m.) administrations of 7 mg/kg body weight (b.w.) to 10 healthy adult goats. Plasma mequindox concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a two-compartment open model and an one-compartment open model for i.v. and i.m. groups, respectively. The elimination half-life and volume of distribution after i.v. and i.m. administrations were statistically different (t1/2β, 1.8 to 1.5 h, P < 0.05 and Vd, 0.35 to 0.45 L·kg-1, P < 0.05, respectively). Mequindox was rapidly (t1/2a, 0.28 h) and almost completely absorbed (F, 99.8%) after i.m. administration. In conclusion, 2~3 times daily i.v. and i.m. administration of mequindox (7 mg/kg b.w.) in goats may be useful in treatment of infectious diseases caused by sensitive pathogens. The plasma disposition kinetics of mequindox in goats is reported for the first time.

Key words: Mequindox, pharmacokinetics, high performance liquid chromatography (HPLC), goats.

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eISSN: 1684-5315