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African Journal of Biotechnology

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Cytotoxic, antibacterial activity and physico-chemical properties of some acid catalyzed Schiff bases

Malik Amanullah, Sher Khan Sadozai, Wajid Rehman, Zonera Hassan, Abdur Rauf, Muhammad Iqbal

Abstract


Some novel Schiff bases have been derived using aromatic aldehydes and aromatic amine in ethanol under acidic conditions. The geometry of these Schiff bases was established using various spectroscopic methods like infrared (IR), nuclear magnetic resonance (NMR) and mass spectrometry. The conductivity studies reveal the non electrolytic behavior of Schiff bases. The synthesized Schiff bases were tested in vitro with the aim of identifying novel lead compounds active against various types of bacteria and shrimps.

Keywords: Acid catalyzed, Schiff bases, NMR, antibacterial activity, brine shrimp




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