Evaluation of antidiarrhoeal activity of the stem bark of Cylicodiscus gabunensis (mimosaceae)

  • MLB Kouitcheu
  • BV Penlap
  • J Kouam
  • BT Ngadjui
  • ZT Fomum
  • FX Etoa
Keywords: Cylicodiscus gabunensis, antidiarrhoeal activity, castor oil

Abstract

The ethyl acetate (EA) extract of the stem bark of Cylicodiscus gabunensis (CG) (Mimosaceae) was analysed for its anti-diarrhoeal activity. Like loperamide (3 mg/Kg body weight), a single oral dose of C.
gabunensis ethyl acetate extract (CG-EA) (375, 750 mg/Kg body weight) produced a significant decrease in the severity of diarrhoea. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit, castor oil induced intestinal fluid accumulation
(enteropooling) and electrolyte concentration in the small intestinal fluid. CG-EA produced a decrease in intestinal transit (10.26-30.75%), and unlike atropine, it significantly inhibited castor oil induced enteropooling. However, it did not alter the electrolyte concentration in intestinal fluid as compared to
castor oil-treated rats
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eISSN: 1684-5315