PROMOTING ACCESS TO AFRICAN RESEARCH

African Journal of Biotechnology

Log in or Register to get access to full text downloads.

Remember me or Register



Usage of U7 snRNA in gene therapy of hemoglobin C disorder: feasibility by gene ontology tool

V Wiwanitkit

Abstract


Hemoglobin (Hb) C disorder is an important hemoglobinopathy with the highest endemicity in Middle East. The red blood cell abnormality is attributed to the beta thalassemic nature of the beta C (bC) globin
gene. Here, a bioinformatic analysis was performed to study the effect of co-expression between human Hb C b-globin chain gene and U7.623. The gene ontological results show that full recovery of hemoglobin function and biological process can be derived. This confirms that U7 snRNA can be a
good tool for gene therapy in Hb C disorder.



AJOL African Journals Online