African Journal of Biotechnology

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Usage of U7 snRNA in gene therapy of hemoglobin C disorder: feasibility by gene ontology tool

V Wiwanitkit


Hemoglobin (Hb) C disorder is an important hemoglobinopathy with the highest endemicity in Middle East. The red blood cell abnormality is attributed to the beta thalassemic nature of the beta C (bC) globin
gene. Here, a bioinformatic analysis was performed to study the effect of co-expression between human Hb C b-globin chain gene and U7.623. The gene ontological results show that full recovery of hemoglobin function and biological process can be derived. This confirms that U7 snRNA can be a
good tool for gene therapy in Hb C disorder.

AJOL African Journals Online