Geographical evolution of the CTX-M ß-lactamase – an update

  • U Govinden
  • C Mocktar
  • P Moodley
  • AW Sturm
  • SY Essack
Keywords: CTX-M -lactamase, geographic evolution, epidemiology.


The CTX-M- type extended spectrum -lactamases (ESBLs) that preferentially hydrolyze cefotaxime are emerging globally and comprise of more than 50 enzymes. The emergence of novel CTX-M - lactamases in several countries is noted as opposed to the transfer of established CTX-M genes from one country to another, suggestive of a de novo dissemination of CTX-M genes.

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eISSN: 1684-5315