Electrolyte profiles in Nigerian patients with essential hypertension

  • GBS Iyalomhe
  • EKI Omogbai
  • RI Ozolua
  • FL Dada
  • OOB Iyalomhe
Keywords: Electrolytes, mild to moderate hypertension, Nigerians.


Information is inadequate on the serum and urine electrolyte profiles in Nigerians with mild to moderate essential hypertension. We, therefore, measured the levels of Na+, K+ and Cl- in 40 adult Nigerians with
untreated uncomplicated mild to moderate hypertension and compared these values with those obtained from age and sex-matched normotensives. Electrolytes were measured using ion-selective
electrolyte analyzer. Mean arterial pressure (MAP) was 127.20 ± 4.20 mmHg in the hypertensives as compared to 92.27 ± 6.25 mmHg in the normotensives. Both groups of subjects had comparable weight
and body mass indices. Results show that in the hypertensives serum, levels of Na+ (152.8 ± 2.14 mmol l-1) and Cl- (115.4 ± 2.62 mmol l-1) were significantly higher than in the normotensives (Na+: 136.0 ± 3.23; Cl-: 102.2 ± 2.52 mmol l-1). Serum K+ levels were significantly lower in the hypertensives than in the normotensives (4.01 ± 0.08 vs 4.82 ± 0.03 mmol l-1). The hypertensives excreted more Na+ (300.9 ± 41.30 mmol l-1) and Cl- (278.6 ± 4.39 mmol l-1) than the normotensives (Na+: 147.10 ± 1.10, Cl-: 126.40 ± 1.51
mmol l-1). Urinary K+ level in the hypertensives was significantly higher than in the normotensives (73.70± 0.73 vs 55.60 ± 0.63 mmol l-1). We conclude that mild to moderately hypertensive Nigerians show
significant differences in their levels of serum and urinary Na+, K+ and Cl- from their normotensive counterparts. The relatively higher serum Na+ and Cl- concentrations and the corresponding lower
serum K+ may indicate their roles in the pathogenesis of hypertension in these patients.

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eISSN: 1684-5315