Hepatoprotective effect of Picrorrhiza kurroa on antioxidant defense system in antitubercular drugs induced hepatotoxicity in rats

  • R Jeyakumar
  • R Rajesh
  • D Rajaprabhu
  • B Ganesan
  • S Buddhan
  • R Anandan
Keywords: Picrorrhiza kurroa, hepatoprotective activity


The hepatoprotective effect of the ethanol extract of Picrorrhiza kurroa rhizomes and roots (PK) on liver mitochondrial antioxidant defense system in isoniazid and rifampicin-induced hepatitis in rats was investigated. In liver mitochondria of antitubercular drugs administered rats, a significant elevation in the level of lipid peroxidation with concomitant decline in the level of reduced glutathione and in the activities of antioxidant enzymes was observed. Co-administration of PK (50 mg/kg/day for 45 days)
significantly prevented these antitubercular drugs-induced alterations and maintained the rats at near normal status.

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eISSN: 1684-5315