AntiMtb activity of triterpenoid-rich fractions from Spondias mombin L.

  • JAO Olugbuyiro
  • JO Moody
  • MT Hamann
Keywords: Spondias mombin, Mycobacterium tuberculosis, triterpenoids.

Abstract

Spondias mombin L. used in traditional medicine because of its antimicrobial properties was found to contain cardiac glycosides, flavonoids, tannins, and anthraquinones in the stem bark. Bioassaydirected
fractionation of the methanol extract of S. mombin was carried out with VLC and HPLC. Isolates were evaluated for antimtb activity which led to the isolation of a series of potential molecules. A semi pure triterpenoid that demonstrated potency of 92.8% inhibition against Mycobaterium
tuberculosis (Mtb) at a concentration of 64 g/ml was further purified by HPLC.
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eISSN: 1684-5315