In vitro trypanocidal effect of methanolic extract of Sclerocarya birrea, Commiphora kerstingii and Khaya senegalensis
Keywords: Trypanosomosis, trypanosome, medicinal plant.
AbstractThe anti-trypanosomal activity of methanolic extract of Sclerocarya birrea, Commiphora kerstingii and Khaya senegalensis were evaluated against Trypanosoma brucei brucei in vitro at concentrations of 2 and 4 mg/ml. Susceptibility of the organism was determined in culture medium containing 5% dextrose and 0.9% saline solution alone as control and 2 and 4 mg/ml of these plants extracts in the same solution. Complete mortality of the organism was observed at almost all the concentrations within 30
min; the organism however survived for almost 3 h in the control test tube. The result suggests that S. birrea, C. kerstingii and K. sengalensis extracts may possess some trypanocidal principles which may require further elucidation.
Copyright for articles published in this journal is retained by the journal.