In vitro activity of certain drugs in combination with plant extracts against Staphylococcus aureus infections

  • G Adwan
  • B Abu-shanab
  • K Adwan
Keywords: Plant extract, antibiotics, drugs, synergism, antagonism, Staphylococcus aureus.


This study has been done to evaluate the interaction between ethanolic extracts of Rhus coriaria (leaf), Psidium guajava (Leaf), Lawsonia inermis (Leaf), and Sacropoterium spinosum (seed) and antimicrobial
drugs including oxytetracyclin HCl, enrofloxacin, gentamicin sulphate, and sulphadimethoxin against 4 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). This evaluation was done by well-diffusion method. Results of this study showed that crude extracts from these plants increase the inhibition zones of oxytetracyclin HCl, gentamicin sulphate, and sulphadimethoxin, while combination between the plant extracts and enrofloxacin decreases inhibition zone.

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eISSN: 1684-5315