Parasiticidal, antifungal and antibacterial activities of Onosma griffithii Vatke

  • B Ahmad
  • N Ali
  • S Bashir
  • MI Choudhary
  • S Azam
  • I Khan
Keywords: Parasiticidal, antileishmanial, antifungal, antibacterial and IC50 values.


Onosma griffithii was screened for possible pharmacological activities. The crude methanolic extract (MeOH) and its fractions demonstrated parasiticidal activity (IC 50 (ìg/ml ± S.D) = 31.03 ± 0.23) against Leishmania major. Based on the IC 50 values, the potency of the standard drug (Pentamidine) and test fractions were of the order as: Pentamidine > crude extract > n-hexane fraction > ethyl acetate (ETOAc) fraction > chloroform fraction (CHCl3) fraction > n-butanol (BUOH) fraction > aqueous fraction. Similarly
moderate antifungal activity was displayed by the crude methanolic extract against Aspergillus flavus and Fusarium solani. Against the Staphylococcus aureus, the aqueous fraction demonstrated moderate antibacterial activity.

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eISSN: 1684-5315