The potential role of flaxseed oil on lead acetateinduced kidney injure in adult male albino rats

Abstract

Lead (Pb⁺²) intoxication may initiate many disorders in humans and animals. This study investigated the role of flaxseed oil in protecting rats against Pb⁺² exposures. The results showed that the administration of flaxseed oil efficiently protected albino rats against the Pb⁺² caused injury, as revealed by some improvement in the histological structure of kidney as well as the restoration of the body weights loss of Pb⁺² treated animals. At the same time, flaxseed oil decreased the levels of serum creatinine, blood urea nitrogen, uric acid, lipid peroxidation and nitric oxide production with concomitant elevation in glutathione, catalase, superoxide dismutase,  glutathione reductase, glutathione-S-transferase and glutathione peroxidase activities. Thus, this study suggests the possibility of flaxseed oil usefulness in limiting toxicant induced by environmental heavy metals.

Key words: Lead, flaxseed oil, kidney, albino rat.