Effect of pineapple (<i>Ananas comosus</i>) on haematological and biochemical parameters in albinos Wistar rats intoxicated with Doliprane

Abstract

The aim of this study is to evaluate the liver’s protection of Ananas comosus on albinos Wistar rats intoxicated with Doliprane® which contained 20% of paracetamol. Four batches of 30 were used. The negative control group was not treated with Doliprane® and A. comosus. Batches no. 2 and no. 3 were treated for six weeks with Doliprane® (2 g per kg of body weight for each day). Each rat of batch 2, has received by cramming, 0.06 ml/kg of body weight for each day of the stalk against 0.12 ml per kg of body weight for each day for batch no. 3. The batch no. 4 has been addicted to Doliprane® (2 g / kg of body weight for each day) and was not treated with A. comosus. A haematological study plus determination of the serum level of glucose, triglycerides and cholesterol was carried out. Doliprane® induced a hypochromic anemia in the rats of batch 4. This anemia has been corrected with the stalk of A. comosus in the rats of batches no. 2 and no. 3. The serum level of glucose and triglycerides increased in the rats of batch no. 4 (p < 0.0001), but that of cholesterol decreased (p < 0.0001). The stalk of A. comosus protects the liver against haematological and biochemical aberrations induced by Doliprane®.

Key words: Ananas comosus (pineapple), hepato-protection, Doliprane®, toxicity.