Biotransformation of ß-estradiol isolated from Sonchus eruca

  • J Hussain
  • Z Muhammad
  • R Ullah
  • N Jamila
  • S Ahmad
  • N Khan
  • S Ayaz
  • S Haider
Keywords: Microbial transformation, ß-estradiol (1, 3, 5-estratriene-3, 17, ß-diols), Bacillus subtillus, Aspergillus niger, lipoxygenase.

Abstract

The biotransformation of ß-estradiol (1,3,5-estratriene-3,17,ß-diols) by Bacillus subtillus resulted in four metabolites which were (1) 3,5-estratriene-3-ol–17–one, (2) 1,3,5-estratriene-3,16,17-triol, (3) 1,3,5,7- estratetra-ene-3-ol-17-one and (4) 1,3,5,6, estratetra-ene-3-ol-17-one. The structures were elucidated on the basis of spectroscopic techniques. Compound 3 showed good inhibitory activity against lipoxygenase enzyme.

Key words: Microbial transformation, ß-estradiol (1,3,5-estratriene-3,17,ß-diols), Bacillus subtillus, Aspergillus niger, lipoxygenase.

Published
2013-09-17
Section
Articles

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eISSN: 1684-5315