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Cancer is the second largest non-communicable disease and it has a sizable contribution in the total number of deaths. Cancer of the urinary bladder ranks fourth in men and eighth in women with an alarming increase in cancer patients of this type every year. Tobacco smoking is considered to be one of the causes of bladder cancer and a number of organic chemicals used in the industry are known to be carcinogenic to the bladder. Chemical and dyestuff manufacturers are at particularly high risk of bladder cancer. Edible fungi are used as potential therapeutic agents for the treatment of cancers. This study was employed to find out the therapeutic potential of two medicinal mushroom varieties namely Pleurotus florida and Calocybe indica against T24 urinary bladder cancer cell lines. The therapeutic potential of the two medicinal mushroom varieties, P. florida and C. indica against T24 urinary bladder cancer cell lines were determined by the MTT assay and DNA fragmentation assay. The results obtained from the MTT assay and DNA fragmentation assay in this study showed the anti-tumour potential of these two mushroom varieties against T24 bladder cancer cell lines. Thus, the mushroom varieties P. florida and C. indica can be employed as potential anticancer drugs against bladder carcinoma.
Key words: Bladder cancer, MTT, DNA fragmentation, mushroom, antitumour.