Study of malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in chickens infected with avian infectious bronchitis virus

  • HF Wang
  • XH Zhong
  • W Shi
  • B Guo
Keywords: Avian infectious bronchitis, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA).

Abstract

This study was carried out to investigate the changes of serum oxidative index in chickens infected with avian infectious bronchitis virus. Eighty (80) 15-day-old chickens were divided into two groups randomly: the control group and the experimental group. Birds in the experimental group were inoculated with infectious bronchitis virus, then the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) contents in the serum were detected in each group at days 1, 3, 6, 9, 12 post infection, respectively. Results showed that SOD and GSH-Px activities in the serum of the experiment group decreased after infection (P<0.05 or P<0.01). MDA contents of the experiment group increased after infection, and was significantly higher than those of the control group at days 6 and 9 post infection (P<0.01). The results implied that oxidative damage may regulate the occurrence and development of avian infectious bronchitis.

Key words: Avian infectious bronchitis, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA).

Published
2013-10-23
Section
Articles

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eISSN: 1684-5315