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African Journal of Biotechnology

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Study of malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in chickens infected with avian infectious bronchitis virus

HF Wang, XH Zhong, W Shi, B Guo

Abstract


This study was carried out to investigate the changes of serum oxidative index in chickens infected with avian infectious bronchitis virus. Eighty (80) 15-day-old chickens were divided into two groups randomly: the control group and the experimental group. Birds in the experimental group were inoculated with infectious bronchitis virus, then the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) contents in the serum were detected in each group at days 1, 3, 6, 9, 12 post infection, respectively. Results showed that SOD and GSH-Px activities in the serum of the experiment group decreased after infection (P<0.05 or P<0.01). MDA contents of the experiment group increased after infection, and was significantly higher than those of the control group at days 6 and 9 post infection (P<0.01). The results implied that oxidative damage may regulate the occurrence and development of avian infectious bronchitis.

Key words: Avian infectious bronchitis, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA).




http://dx.doi.org/10.5897/AJB11.782
AJOL African Journals Online