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African Journal of Biotechnology

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Botrallin from the endophytic fungus Hyalodendriella sp. Ponipodef12 and its antimicrobial activity

L Zhong, L Xu, X Meng, Y Peng, Y Chen, P Sui, M Wang, L Zhou

Abstract


Bioassay-guided fractionation of the crude methanol extract of the mycelia from the endophytic fungus Hyalodendriella sp. Ponipodef12, associated with the hybrid 'Neva' of Populus deltoides Marsh × P. nigra L., led to the isolation of one compound coded as P12-1 which was identified as botrallin (1,7- dihydroxy-3,9- dimethoxy-4a-methyl-6H- dibenzo [b,d] pyran-2,6 (4aH) -dione) by spectroscopic and physicochemical means. The median inhibitory concentration (IC50) and minimum inhibitory concentration (MIC) of botrallin against Bacillus subtilis were 98.47 μg/ml and 200 μg/ml, respectively. The IC50 values of botrallin against spore germination of Magnaporthe oryzae and Botryosphaeria dothidea were 81.62 μg/ml and 110.02 μg/m, respectively. This is the first report about botrallin and its antimicrobial activity from the endophytic fungus Hyalodendriella sp. Ponipodef12 derived from Populus species.

Key words: Poplar hybrid 'Neva', endophytic fungus, Hyalodendriella sp., botrallin, antimicrobial activity.




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