Evaluation of the anti-oxidant and anti-angiogenic effects of Sphenocentrum Jollyanum Pierre

  • R Nia
  • DH Paper
  • EE Essien
  • KC Iyadi
  • AIL Bassey
  • AB Antai
  • G Franz

Abstract

The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti -angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 μg/pellet) on DDPH and anti -angiogenesis assays respectively. Further fractionation of the stem bark revealed the chloroform fraction to have the highest IC50 1.54 ± 0.15 and the most important score on anti - angiogenesis assay with 1.3 ± 0.10 at 250 μg/pellet when serially diluted between 250 and 36.2 μg/pellet. Moreover, the effects were found to be dose-dependent. These results bring to the fore the need for further studies towards confirming the anti -oxidant and anti-angiogenic potentials of the plant as well as identifying and characterizing the active principles for drug development.

African Journal of Biomedical Research Vol. 8(1) 2005: 4750
Published
2006-09-14
Section
Articles

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eISSN: 1119-5096