African Journal of Biomedical Research

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Epidemiological patterns of human immunodeficiency virus and herpes simplex virus co-infection in ibadan, nigeria

O.M Kolawole, F.D Adu, O.O Agbede, A.A Oni, R.A Bakare


There is no doubt that the greatest health problem threatening the human race these times is the HIV/AIDS pandemic. The greatest burden of this scourge is in sub-saharan African. This has undoubtedly increased the incidence of opportunistic infection like herpes simplex virus infection. This study investigated the epidemiological pattern of HIV and HSV co-infection in patients attending the sexually Transmitted Diseases Clinic of University
College Hospital, Ibadan. The findings revealed that a total of 63 patients
presented classical genital ulceration during the period of study. There was
statistical significance between the age group of the patients and their
seropositivity status (x2= 3.86, P< 0.05). The epidemiological studies also
revealed that there was statistical significant difference in development of
genital herpetic ulceration and their HIV seropositivity status (x2= 39.35, P< 0.05). There was also a significant difference between herpes simplex virus CPE formation from genital lesion and the HIV seropositivity status of the patients (x2= 10.96, P< 0.05). Also, there was statistical significant difference in HSV CPE formation from genital lesions of HIV seropositive patients already on antiretroviral therapy (x2= 4.06, P< 0.05). Ballooning
degeneration of cells indicative of CPE of HSV in vero cell lines were
detected within 2-3 days post inoculation. The HIV and HSV Co-infection
pattern among patients attending Sexually Transmitted Diseases Clinic in
University College Hospital, Ibadan is therefore discussed.
(Afr. J. Biomed. Res. 11: 23 -26)

Key words: HIV, HSV, CPE, Serological status
AJOL African Journals Online