Analgesic and Anti-Inflammatory Activities of an Ethanol Extract of <i>Smilax krausiana</i> Leaf in Mice

Abstract

The effect of ethanolic extract of Smilax krausiana (Smilaceae) leaf was investigated for its analgesic and antiinflammatory activities in mice. The extract significantly (p<0.01-0.001) inhibited in a dose – dependent fashion algesia (nociception) induced by acetic acid, formalin and hot plate. It also reduced in dose-related manner inflammation induced by fresh egg albumin, carrageenin and capsaicin. These inhibitions were statistically significant (p<0.01 – 0.001). Though the mechanism of action of the extract is not fully elucidated, it may in part involve suppression of capillary permeability through neurogenic and non-neurogenic pathways as well as its narcotic potential. The extract’s inhibition of all the models investigated in a non-specific manner supports the folkloric use of the plant.

Key Word: Smilax krausiana, ethanol, leaf, analgesic, anti-inflammatory, mice.