Fractional order HIV/AIDS model using Caputo-Fabrizio operator

  • Ebenezar Nkemjika Unaegbu
  • Ifeanyi Sunday Onah
  • Moses Oladotun Oyesanya
Keywords: Mathematical models, HIV/AIDS, Caputo Fabrizio derivative, Existence, Uniqueness and stability, Laplace transform, Numerical simulation.


Background: HIV is a virus that is directed at destroying the human immune system thereby exposing the human body to the risk of been affected by other common illnesses and if it is not treated, it generates a more chronic illness called AIDS.
Materials and Methods: In this paper, we employed the fixed-point theory in developing the uniqueness and existence of a solution of fractional order HIV/AIDS model having Caputo-Fabrizio operator. This approach adopted in this work is not conventional when solving biological models by fractional derivatives.
Results: The results showed that the model has two equilibrium points namely, disease-free, and endemic equilibrium points, respectively. We showed conditions necessitating the existence of the endemic equilibrium point and showed that the disease-free equilibrium point is locally asymptotically stable. We also tested the stability of our solution using the iterative Laplace transform method on our model which was also shown stable agreeing with the disease-free equilibrium.
Conclusions: Numerical simulations of our model showed clear comparison with our analytical results. The numerical solutions show that given fractional operator like the Caputo-Fabrizio operator, it is less noisy and hence plays a major role in making a precise decision and gives room or opportunity (‘freedom’) to use data of specific patients as the model can be easily adjusted to accommodate this, as it a better fit for the patients’ data and provide meaningful predictions. Finally, the result showed the advantage of using fractional order derivative in the analysis of the dynamics of HIV/AIDS over the classical case.


Journal Identifiers

eISSN: 2006-0165