African Journal of Infectious Diseases

The AJOL site is currently undergoing a major upgrade, and there will temporarily be some restrictions to the available functionality.
-- Users will not be able to register or log in during this period.
-- Full text (PDF) downloads of Open Access journal articles will be available as always.
-- Full text (PDF) downloads of subscription based journal articles will NOT be available
We apologise for any inconvenience caused. Please check back soon, as we will revert to usual policy as soon as possible.

Antibacterial and wound healing activities of melastoma malabathricum linn.

J Anbu, P Jisha, R Varatharajan, M Muthappan


Melastoma malabathricum Linn. (Melastomataceae), locally known as senduduk putih, is a wellknown plant in Malaysian traditional medicine. On the basis of its traditional use and literature reference,
this plant was selected for evaluation of its wound healing and antibacterial activities. Methanol extract of M. malabathricum was examined for its wound healing activity in the form of an ointment in two types of wound model in rats: (i) the excision wound model and (ii) the incision wound model. The methanol extract ointment produced a significant response in both of the wound types tested. The results were also comparable with the standard drug, nitrofurazone, in terms of wound contracting ability, wound closure time, tensile strength and regeneration of tissues at the wound site. Regarding antibacterial activity, M. malabathricum extract inhibited the different clinical wound isolates of S. aureus and P. aeruginosa with MIC ranging from 3.0 mg/ml for 3 of the 4 clinical strains of S. aureus to 8.0 mg/ml for all the 3 clinical strains of P. aeruginosa tested.

Keywords: Melastoma malabathricum; Antibacterial; Methanol extract; Wound healing.
AJOL African Journals Online