Reproductive hormones as psychotropic agents?

Abstract

The female preponderance in unipolar mood and anxiety disorders is well documented, with a double to triple lifetime prevalence compared to males. Much of this increased vulnerability is in the childbearing years. Hormones are a tempting explanation, although other biochemical factors such as cytokines may also be important. Psychosocial factors are clearly involved, including role issues.

South African Psychiatry Review - May 2002