The Acute Phase Response to Parturition: A Cross- Sectional Study in Zimbabwe

  • H Friis
  • E Gomo
  • W Mashange
  • N Nyazema
  • P Kæstel
  • F Wieringa
  • H Krarup
Keywords: Acute phase response, 1-antichymotrypsin, C-reactive protein, HIV, postpartum, Zimbabwe

Abstract

Parturition triggers an acute phase response, but its magnitude, duration and predictors are not well described. We determined serum a1-antichymotrypsin (ACT) and C-reactive protein (CRP) among 216
women attending postpartum services in south-eastern Zimbabwe. Serum CRP peaked during the first week and serum ACT around 9 days postpartum. Serum ACT, but not serum CRP, was lower among
HIV infected women. Multiparity was a negative, and preterm delivery and caesarean section were positive predictors of both serum ACT and CRP. There is a need for a better understanding of the acute phase response to parturition (Afr J Reprod Health 2009; 13[2]:61-68).
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eISSN: 1118-4841