Article Sidebar
Published:
Oct 20, 2008Keywords:
<i>Hibiscus sabdariffa</i> plant extract and fractions sub-acute toxicity immuno-modulatory
Article Details
Issue
Section
Articles
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
Main Article Content
Toxicity And Immunomodulatory Activity Of Fractions Of <i>Hibiscus sabdariffa</i> Linn (Family Malvaceae) In Animal Models
Abstract
This study evaluated immunomodulatory properties and the sub-acute toxicity profile of two fractions of the aqueous alcoholic extract of the dried calyx of Hibiscus sabdariffa in experimental animals. Immunomodulatory activity was evaluated using red blood cell-induced immunostimulation. The fractions were not found to be toxic after 7-day administration, though there was severe weight loss with the residual water-soluble fraction (RWSF) and weight gain with the ethyl acetate soluble fraction (EAC). The EAC exhibited a significant dose-dependent immunostimulation (p<0.05) higher than that observed for levamisole (positive control). The residual water-soluble fraction exhibited immunostimulatory activity at 100mg/kg body weight. The two fractions caused a significant reduction in production of tissue necrosis factor – alpha and an increase
in interleukin 10 (IL-10).
Keywords: Hibiscus sabdariffa, plant extract and fractions, sub-acute toxicity, immuno-modulatory activity, cytokine production
African Journal of Trad, Comp and Alternative Medicine Vol. 5 (4) 2008: pp. 394-398
