Hepatoprotective effect and GC-MS analysis of traditionally used Boswellia sacra oleo gum resin (Frankincense) extract in
Background: The water extract of oleo-gum-resin of Boswellia sacra Fleuckiger (Burseraceae) is used in the treatment of liver problems in the Middle East and Arab-African countries. The present study was carried out to evaluate its effect on liver injury induced by carbon tetrachloride in acute and chronic liver injury models.
Materials and Methods: The Boswellia sacra extract was administered at doses of 2 ml/kg and 5 ml/kg. Silymarin, a known hepato-protective agent was used as standard. The extract was subjected to GC-MS analysis to determine the presence of various phyto-constituents.
Results: The Boswellia sacra extract at tested doses of 2 ml/kg and 5 ml/kg significantly reduced the elevated serum levels of biomarkers in liver damage. The hepatoprotective effect was supported by changes in histopathology. The GC-MS analysis of the extract revealed the presence of several phyto-constituents that included menthol, 3-cyclohexen-1-ol and octanoic acid.
Conclusion: The water extract oleo-gum-resin of Boswellia sacra possesses hepatoprotective activity, as claimed by traditional healers within the Middle East and Arab-African countries.
Key words: Boswellia sacra, hepatoprotective, carbon tetrachloride, frankincense, liver damage.
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