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African Journal of Traditional, Complementary and Alternative Medicines

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Astragaloside III from Astragalus membranaceus antagonizes breast cancer growth

S Wang, L Tang, F Chen

Abstract


Background: Astragaloside III has been used to treat different cancers; however their effect on breast cancer remains unknown.
Materials and methods: The present study examined the effects of Astragaloside III from Astragalus membranaceus on breast cancer cell lines in vitro as well as xenograft in vivo.
Results: The results showed that the Astragaloside III could effectively reduce cancer cell survival in vitro and inhibit the tumor growth in vivo. The potential mechanism is the induction of cell apoptosis signaling pathways.
Conclusion: We believe that Astragaloside III provides a new therapeutic tool to treat breast cancer.

Keywords: breast cancer; Astragaloside III; apoptosis; treatment;




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