In vitro anti-inflammatory and free radical scavenging activities of crude saponins extracted from Albuca bracteataJacq. Bulb.
Background: Albuca bracteata is a medicinal plant traditionally used in the management of diabetes mellitus in the Eastern Cape of South Africa. The purpose of this study was to evaluate the antioxidant and anti-inflammatory activities of saponins extracted from the bulb of Albuca bracteata and compared with the crude methanolic extract.
Methods: In vitro antioxidant activity was determined using free radical scavenging assays such as DPPH, ABTS and NO2. The antiinflammatory potential was carried out using inhibition of protein denaturation of egg albumin as a model of anti-inflammatory capacity.
Results: Both the crude methanolic extract and saponins showed inhibition of DPPH, ABTS and NO2 scavenging activity. However, the free radical scavenging activity of isolated saponin compared favourably with Rutin and BHT. The crude methanolic extract showed higher inhibition percentage of protein denaturation compared with the saponins at the concentration investigated.
Conclusion: This study indicates that saponin from Albuca bracteata bulb possess potent anti-inflammatory activity and is also a good source of natural antioxidant.
Key words: anti-inflammatory, Albuca bracteata, free radicals, antioxidants
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.