PROMOTING ACCESS TO AFRICAN RESEARCH

African Journal of Traditional, Complementary and Alternative Medicines

Log in or Register to get access to full text downloads.

Remember me or Register



Assessing effects of Equisetum ramosissimum extract on hematological and serum biochemical parameters in pregnant Sprague-Dawley rats

Hana Dawood Alebous, Arwa Ali Hudeb, Suzanne Ali Sober, Rosianna Gray, Margaret Dean Johnson

Abstract


Background: As a medicinal herb, Equisetum ramossisemum has been utilized for centuries as a diuretic and has been recommended for different disorders. The aim of this study was to investigate the maternal toxicity of aerial parts of Equisetum ramosissimum extract on pregnant Sprague-Dawley rats.

Methods: Females were mated and the coupling time was recorded at gestation day 0– E0. Four experimental groups I, II, III, and IV, received daily gavage doses of 0 mg, 500 mg, 250 mg, and 125 mg/kg, respectively, of Equisetum ramosissimum extract. Pregnant rats were observed for mortality and toxicological effects during daily treatment. On day E20, samples of blood were withdrawn from the retro-orbital sinus under light ether anaesthesia for haematological and clinical chemistry examinations.

Results: Data analyses detected significant differences in biochemical and haematological parameters between the control group and other groups receiving extract.

Conclusion: This study constitutes a first approach to defining adverse effects of using Equisetum ramosissimum as a medicinal plant during pregnancy. Daily gavage doses of Equisetum ramosissimum extract produced significant differences in biochemical and haematological parameters in pregnant Sprague-Dawley rats as compared to the control group.

Keywords: Equisetum ramosissimum extract; Pregnant Sprague -Dawley rats; Haematology; Serum




AJOL African Journals Online