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African Journal of Traditional, Complementary and Alternative Medicines

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The preventive effect and enhance immunity function of Bu-zhong-yi-qi wan on s180 tumor mice

Fang Hu, Xiao-ya Liu, Xin-yue Chen, Can Li, Rui-juan Zhu, Huan Huan, Ying-dong Li, Shi-lan Feng

Abstract


Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo.

Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1×107/ml) at the right oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and phagocytosis activity of peritoneal macrophages were done. Interferon (IFN-γ), interleukin (IL-2) and tumor necrotic factor (TNF-α) in serum were detected.

Results: In the S180 tumor-bearing mice, Bu-zhong-yi-qi wan with medium-dose (975 mg/kg, 100 mg/l) had potent preventive effect and anti-tumor effect, macrophage phagocytosis and Con A-stimulated splenocyte proliferation were increased as compared with model control treatment. Bu-zhong-yi-qi wan could take part in the immune response by promoting the proliferation and differentiation of Tcells, increasing the activity of the macrophages, inducing the generation of cell factor IL-2, TNF-α, IFN-γ.

Conclusion: It proved that Bu-zhong-yi-qi wan of medium-dose had great preventive effect and could enhance immunity function.

Keywords: Bu-zhong-yi-qi wan, S180 tumor-bearing mice, preventive, immunity




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