African Journal of Traditional, Complementary and Alternative Medicines

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Antitrichomonal activity of 1,3-diaryl-2-propen-1-ones on Trichomonas gallinae

AO Oyedapo, VO Makanju, CO Adewunmi, EO Iwalewa, TK Adenowo


1,3-diaryl-2-propen-1-ones were synthesized by the Claisen - Schmidt condensation method. T. gallinae parasites isolated from domestic pigeon were cultured in vitro. The in vitro susceptibility of T. gallina was evaluated in multi-well plates at 37oC. Four of the synthetic compounds produced significant antitrichomonal activity against T. gallinae. The minimal lethal concentrations (MLCs) (produced by) 2\'-hydroxy-4- methoxychalcone, 2\'-hydroxy-2,4\'-dimethoxychalcone, 2\'-hydroxy-4-chlorochalcone, 3,4,4\'-Trimethoxychalcone and 4-hydroxcychalcone were 100.0, 0.78, 50.0, 50.0 and 3.13 µg/ml respectively. The results indicate that 2\'-hydroxy-2,4\'-dimethoxychalcone and 3 other synthetic 1,3-diaryl-2-propen-1-ones possess potent antitrichomonal activity against T. gallinae. However, the studies on cytotoxicity effect showed that all the active chalcones demonstrated a very low haemagglutination titre values ranging between 0.57 – 4.06 suggesting their low toxicity profile.

Key Words: Trichomonas gallinae, 1,3-diaryl-2-propen-1-ones, in vitro activity

Afr. J. Trad. CAM (2004) 1: 55-62

AJOL African Journals Online