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African Journal of Traditional, Complementary and Alternative Medicines

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Evaluation of Analgesic, Anticonvulsant and Hypnotic activities of Pyrenacanthia staundtii

EO Awe, JM Makinde, OA Olajide, OK Wahkeel, AO Adeloye

Abstract


An Aqueous leaf extract of Pyrenacanthia Staundtii (AqPs) was studied for central nervous activities. The extract (100.0 – 400.0 mg/kg i. p). significantly (p<0.05) inhibited acetic-acid induced abdominal constriction, and both the early and or late phases of formalin induced paw licking in mice. AqPs (100-400mg/kg i.p.) also demonstrated a protective effect against strychnine-induced convulsion. The extract potentiated the hypnotic effect of hexobarbitone following i.p. injection at the dose levels studied. The results suggested that AqPs possesses potential analgesic, anticonvulsive and hypnotic properties.
Key Words: Pyrenacanthia staundtii, Analgesic activity, Anticonvulsive, Hypnotic effects.
Afr. J. Trad. CAM (2005) 2 (2): 122-128



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