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African Journal of Traditional, Complementary and Alternative Medicines

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Short Communication: The antiulcer effects of the methanol extract of the leaves of Aspilia africana (Asteraceae) in rats

Télesphore Benoît Nguelefack, Pierre Watcho, Sylvie Lea Wansi, Ngetla Manyineh Mbonuh, Dieudonne Ngamga, Pierre Tane, Albert Kamanyi

Abstract


Aspilia Africana (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of A. africana was investigated against gastric ulcerations induced by HCl/ethanol and pylorus-ligation. With both methods, the extract inhibited gastric ulcerations in a dose-related manner. Oral administration of the plant extract at the doses of 0.5 and 1 g/kg reduced gastric lesions induced by HCl/ethanol by 79% and 97% respectively. The extract at the dose of 1 g/kg reduced gastric lesion in the pylorus ligated rats by 52% although the gastric acidity remained higher as compared to the control. These findings show that methanol extract of the leaves of A. Africana possess potent antiulcer properties.
Key words: Aspilia Africana, antiulcer, rat
Afr. J. Trad. Comp. Alt. Med. Vol.2(3) 2005: 233 - 237



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