Antidiabetic activity of ethanolic leaf extract of Croton zambesicus Muell.(thunder plant) in alloxan diabetic rats

  • JE Okokon Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • AL Bassey
  • J Obot

Abstract

Antidiabetic activity of ethanolic leaf extract of Croton zambesicus Muell. Arg. was evaluated using alloxan-induced (150mg/kg) hyperglycaemic rats. The activity of the ethanolic leaf extract was compared with that of a reference drug Chlorpropamide. The Blood Glucose Levels were measured using glucometer. The extract produced a significant (P<0.01) reduction in BGL after a single dose of the extract and in prolonged treatment (for 7 days). The antidiabetic activity was comparable to that of the reference drug-chlorpropamide.

Keywords: Croton zambesicus, antidiabetic, alloxan

African Journal of Traditional, Complementary and Alternative Medicines Vol. 3(2) 2006: 21-26
Published
2006-08-21
Section
Articles

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eISSN: 0189-6016