The antiplasmodial agents of the stem bark of Entandrophragma angolense (Meliaceae).

  • J Bickiia
  • GRF Tchouyab
  • JC Tchouankeub
  • E Tsamo
Keywords: <i>Plasmodium falciparum</i>, Meliaceae, <i>Entandrophragma angolense</i>, Limonoids, Fatty acids, Triterpenoids, 7&#945, -obacunyl acetate, 24-methylenecycloartenol, anti-plasmodial activity.


In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane – methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7α-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 μg/ml respectively. Other compounds were moderately active.

Keywords:Plasmodium falciparum; Meliaceae;Entandrophragma angolense; Limonoids; Fatty acids; Triterpenoids; 7α-obacunyl acetate; 24-methylenecycloartenol; anti-plasmodial activity.

African Journal of Traditional, Complementary and Alternative Medicines Vol. 4 (2) 2007: pp. 135-139

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eISSN: 0189-6016