The antiplasmodial agents of the stem bark of Entandrophragma angolense (Meliaceae).
In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane – methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7α-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 μg/ml respectively. Other compounds were moderately active.
Keywords:Plasmodium falciparum; Meliaceae;Entandrophragma angolense; Limonoids; Fatty acids; Triterpenoids; 7α-obacunyl acetate; 24-methylenecycloartenol; anti-plasmodial activity.
African Journal of Traditional, Complementary and Alternative Medicines Vol. 4 (2) 2007: pp. 135-139
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