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Antigenotoxic Effect Of Ferulic Acid In 7,12-Dimethyl Benz(A)- Anthracene (Dmba) Induced Genotoxicity

S Balakrishnan
VP Menon
S Manoharan
K Rajalingam


The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12- dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30mg kg-1 b.w). Pretreatment of ferulic acid orally at a dose of 40mg kg-1 b.w for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster\'s bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced
genotoxicity in golden Syrian hamsters.

Keywords: DMBA, ferulic acid, genotoxicity, chromosomal aberrations, lipid peroxidation, antioxidants,

African Journal of Traditional and Complementary Medicine Vol. 5 (1) 2008: pp. 32-38

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eISSN: 0189-6016