Anti-Nociceptive And Anti-Inflammatory Activities Of Ethanol Extract Of Syzygium aromaticum Flower Bud In Wistar Rats And Mice
The ethanol extracts of Syzygium aromaticum flower bud were tested for anti-nociceptive and antiinflammatory effects in mice and Wistar rats which were carried out using acetic acid-induced abdominal contractions in mice and formalin-induced hind paw edema in Wistar rats. Three doses of the ethanol extract (50, 100, and 200mg/kg body weight i.p.) were used for both studies. The extract had an LD50 of 565.7 mg/kg body
weight intraperitoneally in mice. The extracts produced significant effect (P<0.05) at all the three doses. Similarly, the anti-nociceptive activity produced significant effects (P<0.05) at all the three doses of the extract. The result supports the local use of the plant in painful and inflammatory conditions.
Keywords: Syzygium aromaticum flower bud, anti-inflammatory, anti-nociceptive; Anti-Inflammatory; Acetic acid-induced abdominal constriction.
Afr. Jnl of Trad Comp Alt medicine Vol. 5 (2) 2008: pp. 209-212