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African Journal of Traditional, Complementary and Alternative Medicines

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Studies On Effect Of Piperine On Oral Bioavailability Of Ampicillin And Norfloxacin

K Janakiraman, R Manavalan

Abstract




Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t½ of the above antibiotics in animal model.

Keywords: Ampicillin, Bioavailability, Norfloxacin, Phamacokinetics, Piperine, Piper nigrum.

African Journal of Trad, Comp and Alternative Medicine Vol. 5 (3) 2008: pp. 257-262



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