The effects of β-elemene on the expression of mTOR, HIF-1α, surviving in lung adenocarcinoma A549 cell
The purpose of this manuscript was to study the regulation effects of â-elemene combined with radiotherapy on three different gene expressions in lung adenocarcinoma A549 cell. mTOR gene, HIF-1á gene, Survivin gene were included in the gene group. Cell culture and RT-PCR were applied to finish this research. Hypoxia Control group, Hypoxia â-elemene group, Hypoxia â-elemene combined with irradiation group were set to compare the differences of three different gene expressions. The most active effects were found in the group of Hypoxia irradiation combined with â-elemene. In this group, the mTOR gene, HIF-1á gene, Survivin gene expressions were all down-regulated when compared with the single treatment groups, and
there were significantly statistical differences.
Key words: â-elemene, A549, mTOR, HIF-1á, Survivin, Rhizoma Curcumae.