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African Journal of Traditional, Complementary and Alternative Medicines

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Experimental study on the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells

SQ Wen, Q Chen, M Hu

Abstract


Backgroud: Cantharidin, and its derivatives can not only inhibit the proliferation of tumor cells, but can also induce tumor cell apoptosis. It shows cantharidin exhibits a wide range of reactivity in anticancer. The objective of this paper was to study the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
Materials and Methods: MTT assay was used to detect the proliferation of HepG2 cells, and immunohisto-chemical method was used to detect the change in VEGF, protein level, and to determine the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
Results: As results, sodium cantharidinate significantly inhibited the growth of HepG2 cells in a time-and dose-dependent manner.
Conclusion: We conclude that sodium cantharidinate has an inhibitory effect on human hepatoma HepG2 cells.

Key words: sodium cantharidinate; human hepatoma HepG2; MTT assay




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