Cytokines in the interface of metabolomics based cancer and type-2 diabetes

Abstract

Changes in the normal intermediate metabolites of glycolysis and the tricarboxylic acid cycle due to constitutive expression of myokines/cytokines in tumor cells and tissues can provide a prognosis for the future cure and prevention of deadly diseases such as cancer. The current review covers the role of immune mediators called cytokines that are produced by inflammatory cells and other related cells such as adipocytes in the genesis of organ specific cancer such as liver and lung cancer. It has been found that in over-nutrition or starving conditions, metabolic processes change, leading to many abnormalities such as obesity and metabolic inflammation giving rise to metabolic disorder based diseases including cancer. The subsequent macro-environments and micro-environments play a crucial role in the genesis as well as progression of the tumor metabolism disorder, chondrosarcoma, and could be future therapeutic targets to prevent and cure abnormal intermediate metabolite and cytokine based diseases particularly type-2 diabetes, liver cancer and lung cancer.

Key words: Tumor biology; Metabolomics; Myokines; Cytokines; Cancer