Comparative Efficacy Of Ancylol, Ivomec, Mebendazole And Piperazine Against <i>Ancylostoma caninum</i> In Experimentally Infected Pups

Abstract

The efficacy and side effects of single dose treatment at different dose regimen of four anthelmintics against Ancylostoma caninum in experimentally infected pups were evaluated and compared based on total worm count and egg per gram (epg) count. Ancylol at both normal (1 mg/kg/BW) and elevated dose level (1.5 ml/kg/BW) showed 93.15 % and 93.87% (based on worm count) and 93.13 and 93.75 % (based on epgcount) respectively. Whereas Ivomec® (a brand of Ivermectin) at normal dose level (1 ml/50 kg) and elevated dose level (1.5 ml/50 kg) was found to be effective. The resuls were 79.48 % and 86.81% based on worm count and 89.44 % and 9250 % based on epg count. Mebendazoe and Pperazine even at elevated dose level was observed ineffective. Pups treated at normal and elevated dose level revealed acute toxicosis whereas those treated with Mebendazole showed cough and vomiting tendencies which later subsided and also, there was no risk involved in the adminisration of the drugs. Statistical analysis showed that there was statistical difference (P < 0.05) in the efficacy of the drugs. However there was signifcant dference (P < 0.05) between % efficacy and dosage. There was also significan difference between (P < 05) between epg count and drugs. The use of various compounds against ancylostomiasis in dogs has been discussed.

Keywords:Anthelmintics, Efficacy, Ancylostoma caninum

Animal Research International Vol. 3 (3) 2006 pp. 540-544