African Perspective of Medication Safety in the Management of Covid-19: A Narrative Review

Abstract

Background: This study highlights the current medication of use for COVID-19 treatment and management in the health care system and the available drugs of use were evaluated for safety profiles. The findings highlight the need for medications such as Remdesivir, Ibuprofen, non-steroidal drugs, and corticosteroids to be extensively studied in the proper management of COVID-19 while reducing its potential side effects. The study also emphasized the need for strong scientific evidence to support the usage of these drugs among those infected with COVID-19. Remdesivir was reported to have no adverse effects related to its usage. In combination with Ritonavir, Lopinavir has shown more promise in managing SARS-CoV and MERS-CoV. There is no available data yet on the use of Ibuprofen, while Umifenovir and Oseltamivir have no scientific basis for an effective fight against the COVID-19 virus. Methylprednisolone and steroids are not recommended for COVID-19 treatment, excluding those affected with Acute Respiratory Distress Syndrome (ARDS), while Tocilizumab was only suggested as a possible COVID-19 medication. These findings have contributed to revealing the kind of COVID-19 medications that are safe for use, a possible suggestion of use, and not recommended. It has abreast us with all the approved medications employed in the care of COVID-19, as it is vital for therapeutic success.   

Methods: This study reviewed the safety profiles of various medications that have been used to treat COVID-19. A literature search was conducted using the PubMed/MEDLINE and Google Scholar search engines. Articles published in English without a date restriction were reviewed.

Results: The results of the study showed that there is limited evidence to support the use of some medications for the treatment of COVID-19. For example, there is no evidence that ibuprofen is effective against the virus. Other medications, such as remdesivir and corticosteroids, have shown some promise in clinical trials, but more research is needed to confirm their safety and efficacy.

Conclusion: The study concluded that there is a need for more research to determine the safety and efficacy of medications for the treatment of COVID-19. In the meantime, healthcare professionals should carefully consider the risks and benefits of using any medication for this purpose.