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Alexandria Journal of Medicine

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Association of IL-23R gene single nucleotide polymorphism; rs 11209026 with incidence and severity of ankylosing spondylitis in a cohort of Egyptian patients

Mohamed I. Sayed, Doaa I. Hashad, Eman A. Soliman, Maha M. Talaaba

Abstract


The aim of the present study was to investigate the possible association between incidence and severity of ankylosing spondylitis (AS) in a cohort of Egyptians and Interleukin-23Receptor (IL23R) genesingle nucleotide polymorphism(rs11209026).

Methods: The study included thirty-two AS patients and forty volunteers who serves as a control group. The studied polymorphismwas genotyped using 50 Nuclease assay.

Results: A statistically significant difference was detected between both studied groups as regards different IL23R genesingle nucleotide polymorphism (rs11209026) genotypes. Heterozygous genotype was the most prevailing among both cases and controls. At a cutoff level of 110 pg/mL, a statically significant difference was observed between cases and controls as regards serum IL23 level.

Conclusions: In Egyptians, IL-23R single nucleotide polymorphism (rs11209026) appears to be associated with ankylosing spondylitis occurrence not severity, while higher levels of IL-23 might be associated with disease severity.

Keywords: Interleukin 23 receptor, Polymorphism, rs 11209026, Ankylosing spondylitis




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