PROMOTING ACCESS TO AFRICAN RESEARCH

Bulletin of Animal Health and Production in Africa

Log in or Register to get access to full text downloads.

Remember me or Register



DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Effects of anti-tick vaccines, recombinant serine protease inhibitors (RAS-1-2) and RIM 36 antigens against Rhipicephalus appendiculatus ticks’ feeding on Zebu cattle in Uganda

J W Magona, C M B Ssekitto, W T Mwayi, J Walubengo, C P Otim, C Sugimoto, M Onuma

Abstract


A preliminary trial of a cocktail of recombinant RAS-1-2 and RIM 36 antigens was conducted in Uganda to assess the effects of ant-tick vaccines against Rhipicephalus appendiculatus tick feeding on Zebu cattle under both experimental and natural conditions. Under experimental conditions, over a period of 28 days, the vaccinated group (n = 5) registered a mean female tick engorgement weight of 147.7 ± 41.8, mean tick egg weight of 90.5 ± 37.9, mean egg hatchability rate of 87.0 ± 12.1 and mean days ticks took to drop off of 6.4 ± 0.4 as opposed to the unvaccinated group (n =5) that had a mean female tick engorgement weight of 175.4 ± 63.0, mean tick egg weight of 99.7 ± 39.4, mean egg hatchability rate of 100 ± 9.6 and mean days ticks took to drop off of 6.4 ± 0.4. Upon exposure to natural tick challenge over a period of 61 days, there was no difference in total tick counts between the vaccinated group (mean tick count= 2-9) and non-vaccinated group (Mean tick count = 2-9) for the first 38 days. However, thereafter over a period of 23 days, tick counts for the vaccinated group (mean tick count = 3) were consistently much lower than those of the non-vaccinated group (mean tick count = 6) on exposure to natural tick challenge. In conclusion, the study revealed that a cocktail of recombinant RAS-1-2 and RIM 36 antigens had effect against tick feeding on Zebu cattle under both experimental and natural conditions with an efficacy rate of 65 % against R. appendiculatus under experimental conditions.

Key words: Anti-tick vaccines; RAS-1-2; RIM 36; R. appendiculatus; Zebu cattle; Uganda




AJOL African Journals Online