Glycated haemoglobin (HBA1C): an update on available methods

Abstract

Glycated haemoglobin (HbA1c) assays give a retrospective index of the integrated plasma glucose over an extended period, usually 90-120 days. This period is, however dependent on the average red cell lifespan of the individual. Since its discovery in the 20^th century, improvement in the analytical techniques for HbA1c have facilitated its wide acceptance as a useful tool in monitoring glucose control, and more recently, has been recommended for the diagnosis of diabetes mellitus. This review provides an update on the methods available for estimating HbA1c levels in the light of their suitability, advantages, and drawbacks.

Keywords: Analytical Methods, Diabetes Mellitus, Glycated Haemoglobin (HbA1c)