An overview on significant human genetics modification in the protection against severe <i>Falciparum</i> malaria

Abstract

This paper was aimed at expatiating the relevance to which falciparum malaria are protected due to various genetically modified factors which include Hemoglobin S, Hemoglobin E, Hemoglobin C, Hemoglobin F, Alpha and beta thalassemia, ovalocytosis, Glucose – 6- Phosphate dehydrogenase deficiency, Human leucocyte antigen (HLA) – BW53, DRBI 1302, DQBI 0501, Pyruvate kinase or PKLR gene. However, human genetics is one of the elements can be used in planning of co- ordinated attack on disease, since it sometime give an avenue to differentiate those groups or individual who are susceptible from those who are not.

Keywords: malaria, hemoglobin, genetically modified factors