Aqueous white grubs extract, Hepatoprotective, Liver damage, CCl
The effects of aqueous white grubs extract on some markers of liver injury was studied in guinea pigs with CCl4-induced liver damage. Serum levels of aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), cholesterol and triglyceride were analysed in guinea pigs after subcutaneous administration of 100mg/kg CCl4 followed by oral treatment with 0.834g/kg of white grub extract in order to asses the curative effect of the extract against liver damage. Guinea pigs treated with 0.834g/kg extract for 48 hours following subcutaneous injection of 100mg/kgCCl4 had serum AST, ALT and ALP levels not statistically different compared to normal control (at p>0.05) but decreased significantly compared to toxicity control (p>0.05). The serum levels of cholesterol and triglyceride in the test showed no statistical difference (at P>0.05) compared to normal control. However, comparing the test values with toxicity control shows a significant increase in both cholesterol and triglyceride levels (at P<0.05). The serum levels of AST, ALT, ALP, cholesterol and triglyceride when the treatment was extended to 96 hours also showed no statistical difference compared to normal control (at P>0.05). However, there was a significant decrease in serum AST, ALT and ALP while serum cholesterol and triglyceride were significantly increased compared to toxicity control (at P<0.05). This result clearly indicates aqueous that white grubs’ aqueous extract possess hepatoprotective property against CCl4 induced liver damaged in guinea pigs.