Simple grinding-induced reactions of 2-aminobenzyl alcohol and benzaldehyde derivatives, a rapid synthetic route to 3,1-benzoxazines

Abstract

The grinding-induced reactions of 2-aminobenzyl alcohol and benzaldehyde derivatives in the presence of 30 mol% of acetic acid to give 3,1-benzoxazines are described. The reactions were performed at room temperature affording 3,1-benzoxazines in yields above 95% and high purity when benzaldehyde and its chloro and nitro derivatives were used.

KEY WORDS: 2-Aminobenzyl alcohol, Benzaldehyde, Acetic acid, 3,1-Benzoxazines

Bull. Chem. Soc. Ethiop. 2014, 28(2), 301-304.

DOI: http://dx.doi.org/10.4314/bcse.v28i2.14